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Small Molecule X

Company: Bristol-Myers Squibb
Location: New Brunswick
Posted on: September 16, 2020

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. The Materials Science and Engineering group at Bristol Myers Squibb is looking for a qualified candidate to fill a temporary position (approximately 6 months) with our Small Molecule X-ray Crystallography team. This position will involve working with team members to grow and characterize crystalline materials of small molecule compounds as well as providing support for ongoing research projects involving crystal engineering. Candidates should have experience in crystallization and the solid state chemistry of small molecule, drug-like compounds. Hands-on experience performing small molecule single crystal X-ray diffraction and/or powder X-ray diffraction experiments a definite plus. Responsibilities will include: - To conduct crystallization/recrystallization experiments small and/or poor crystallinity samples - To design and execute single crystal growth experiments of drug molecules to help identify polymorph, salt & co-crystal form candidates. Depending on candidate qualifications, responsibilities may also include: - To determine the crystal structures of small molecule drug candidates and key intermediates - Use single-crystal X-ray Diffraction techniques to determine 3-Dimensional arrangements of atoms within a crystal. - Use software visualization and analysis tools to assess packing arrangements, intra- and intermolecular interactions, and other structural properties affecting solubility and stability. - To perform solid state characterization of drug substances using various analytical techniques such as PXRD, TGA, DSC, spectroscopy, PLM and DVS. Qualifications Required: - Ph.D. or nearing Ph.D. completion in Chemistry, Chemical Engineering, Pharmaceutical Science, Materials Science or a related field with 0-3 years of relevant work experience. - . in Chemistry, Chemical Engineering, Pharmaceutical Science, Materials Science or a related field with 5-7 years of relevant work experience. - Knowledge in physical and solid-state chemistry of organic molecules. - Experience in crystallization techniques for small molecule, drug-like compounds - Familiarity with the Cambridge Structural Database and associated software Desired: - Hands-on experience in single crystal & powder X-ray diffraction, small molecule crystallography, - Hands-on experience with other solid form characterization techniques such as DSC, TGA, IR and Raman spectroscopy Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Keywords: Bristol-Myers Squibb, New Brunswick , Small Molecule X, Other , New Brunswick, New Jersey

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