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Toxicokinetic Scientist - New Brunswick

Company: Bristol-Myers Squibb Company
Location: New Brunswick
Posted on: September 4, 2019

Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis. Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results. This person is responsible for supporting pharmacokinetic/toxicokinetic strategy for the preclinical development of small molecules and protein therapeutics within Drug Safety Evaluation (DSE). The candidate will have a strong background in pharmacokinetics and drug metabolism, and will serve as the key contact for all pharmacokinetic/toxicokinetic (PK/TK)-related issues pertinent to the development of assigned drug candidates. As part of the DSE Toxicokinetics group, the candidate will serve as a contributor scientist/principal investigator onDSE studies and execute PK/TK and PK/PD strategies; will closely interact with DSE study directors and project representatives, as well as colleagues from bioanalytical, drug metabolism, and other relevant functional areas. Job Responsibilities Serve as a Subject Matter Expert for all TK-related issues pertinent to the development of assigned drug candidates. Serve as a contributing scientist on toxicology studies and execute all phases/aspects of the toxicokinetics evaluation with minimum supervision. Essential duties include, but are not limited to the following: provide TK study design, use TK modeling to support study dose selection, calculate PK/TK parameters, provide TK data interpretation, and write TK reports that meet internal and external standards. Deliver high quality scientific results according to agreed timeline for several concurrent studies. Prepare or coordinate the preparation of toxicokinetic summaries, as needed, in support of the registration of drug candidates or in response to requests from regulatory authorities. Effectively communicate study results at internal meetings, as appropriate. Use judgment and knowledge where appropriate to influence project team decision making. Create an atmosphere of scientific excellence, open communication, and creativity in order to maximize productivity Ensure the compliance with Good Laboratory Practice, Standard Operating Procedures, and study protocols in conducting toxicology studies. Ensure compliance with all company/departmental policies, as well as other federal, state and corporate policies and guidelines particularly those relating to animal welfare and employee safety and health. Evaluate and apply new scientific methodology in order to maintain scientific excellence, to meet research and drug-registration needs, and to minimize or resolve toxicity-based problems with company products or those under development Position requirements BS/MS/PhD in Pharmacometrics, Pharmaceutics, Toxicology, Pharmacology, or other related scientific disciplines. BS/MS or equivalent with minimum 2-7 years related experience or PhD degree with minimum 0-1 year related experience. Excellent verbal and written communication skills as well as organizational skills. Must demonstrate strong work ethics and problem solving skills. Knowledge of the general principles of pharmacokinetics, drug metabolism, animal and human biology and physiology. Experience in PK/PD modeling software (eg, Phoenix WinNonlin) desirable. Proficient in Microsoft Word and Excel. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Keywords: Bristol-Myers Squibb Company, New Brunswick , Toxicokinetic Scientist - New Brunswick, Other , New Brunswick, New Jersey

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